The TEAD family of transcription factors is necessary for developmental processes. The
family members contain a TEA domain for the binding with DNA elements and a …

The Hippo pathway is a central regulator of organ size and tissue homeostasis. Hippo
kinases and adaptor proteins mediate the phosphorylation and inactivation of YAP and TAZ …

Abstract Background Non-coding RNAs (ncRNAs) have been shown to regulate gene
expression involved in tumor progression of multiple malignancies. Our previous studies …

Ovarian cancer is the deadliest gynecologic cancer. Despite recent advances, clinical
outcomes remain poor, necessitating novel therapeutic approaches. To investigate …

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …

Ovarian cancer is one of the top gynecological malignancies that cause deaths among
females in the United States. At the molecular level, significant progress has been made in …

The epithelial–mesenchymal transition (EMT) plays a pivotal role in the differentiation of
vertebrates and is critically important in tumorigenesis. Using this evolutionarily conserved …

The Hippo pathway, initially identified through screenings for mutant tumor suppressors in
Drosophila, is an evolutionarily conserved signaling pathway that controls organ size by …

Therapeutic application of microRNAs (miRNAs) in Wnt-driven glioma has been valuable;
however, their specific roles and mechanisms have not been completely investigated. Real …

Gynecological cancers (GCs) are often diagnosed at advanced stages, limiting the efficacy
of available therapeutic options. Thus, there remains an urgent and unmet need for …