Human vitreous in proliferative diabetic retinopathy: characterization and translational implications

IM Nawaz, S Rezzola, A Cancarini, A Russo… - Progress in retinal and …, 2019 - Elsevier
Diabetic retinopathy (DR) is one of the leading causes of visual impairment in the working-
age population. DR is a progressive eye disease caused by long-term accumulation of …

Cell and molecular targeted therapies for diabetic retinopathy

SK Reddy, V Devi, ATM Seetharaman… - Frontiers in …, 2024 - frontiersin.org
Diabetic retinopathy (DR) stands as a prevalent complication in the eye resulting from
diabetes mellitus, predominantly associated with high blood sugar levels and hypertension …

Assessment of neurotrophins and inflammatory mediators in vitreous of patients with diabetic retinopathy

JD Boss, PK Singh, HK Pandya, J Tosi… - … & visual science, 2017 - iovs.arvojournals.org
Purpose: To assess vitreous levels of inflammatory cytokines and neurotrophins (NTs) in
diabetic retinopathy (DR) and elucidate their potential roles. Methods: A prospective study …

A journey into the retina: Müller glia commanding survival and death

PV Subirada, MC Paz, ME Ridano… - European Journal of …, 2018 - Wiley Online Library
Müller glial cells (MGC s) are known to participate actively in retinal development and to
contribute to homoeostasis through many intracellular mechanisms. As there are no …

Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy

K Kaviarasan, M Jithu, MA Mulla, T Sharma… - Metabolism, 2015 - Elsevier
Objective The study was conducted to observe the serum and vitreous levels of LXA 4,
BDNF and Th1/Th2 cytokines in type 2 diabetes mellitus (DM) and changes associated with …

Neuroprotection as a therapeutic target for diabetic retinopathy

C Hernández, M Dal Monte, R Simó… - Journal of diabetes …, 2016 - Wiley Online Library
Diabetic retinopathy (DR) is a multifactorial progressive disease of the retina and a leading
cause of vision loss. DR has long been regarded as a vascular disorder, although neuronal …

Mechanism of pain generation for endometriosis-associated pelvic pain

H Kobayashi, Y Yamada, S Morioka, E Niiro… - Archives of gynecology …, 2014 - Springer
Purpose Endometriosis-associated pelvic pain appears due to persistent nociceptive
stimulation, but the precise mechanisms remain poorly understood. Methods A search was …

Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT)

AMA El-Asrar, G De Hertogh, K van den Eynde… - Experimental eye …, 2015 - Elsevier
Myofibroblasts expressing α-smooth muscle actin (α-SMA) are the key cellular mediator of
fibrosis. Fibrovascular epiretinal membranes from patients with proliferative diabetic …

Identification of proteins associated with clinical and pathological features of proliferative diabetic retinopathy in vitreous and fibrovascular membranes

I Klaassen, EW De Vries, IMC Vogels… - PLoS …, 2017 - journals.plos.org
Purpose To identify the protein profiles in vitreous associated with retinal fibrosis,
angiogenesis, and neurite formation in epiretinal fibrovascular membranes (FVMs) in …

[HTML][HTML] The protective effects of neurotrophins and microRNA in diabetic retinopathy, nephropathy and heart failure via regulating endothelial function

S Shityakov, M Nagai, S Ergün, BM Braunger… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus is a common disease affecting more than 537 million adults worldwide.
The microvascular complications that occur during the course of the disease are widespread …