[HTML][HTML] Antifreeze proteins: Novel applications and navigation towards their clinical application in cryobanking

MD Ekpo, J **e, Y Hu, X Liu, F Liu, J **ang… - International Journal of …, 2022 - mdpi.com
Antifreeze proteins (AFPs) or thermal hysteresis (TH) proteins are biomolecular gifts of
nature to sustain life in extremely cold environments. This family of peptides, glycopeptides …

Space microgravity increases expression of genes associated with proliferation and differentiation in human cardiac spheres

H Hwang, A Rampoldi, P Forghani, D Li, J Fite… - npj …, 2023 - nature.com
Efficient generation of cardiomyocytes from human-induced pluripotent stem cells (hiPSCs)
is important for their application in basic and translational studies. Space microgravity can …

[HTML][HTML] Space microgravity improves proliferation of human iPSC-derived cardiomyocytes

A Rampoldi, P Forghani, D Li, H Hwang, LC Armand… - Stem Cell Reports, 2022 - cell.com
In microgravity, cells undergo profound changes in their properties. However, how human
cardiac progenitors respond to space microgravity is unknown. In this study, we evaluated …

[HTML][HTML] Cardiovascular adaptations of space travel: a systematic review

SN Sharma, LLT Meller, AN Sharma, EA Amsterdam - Cardiology, 2023 - karger.com
Introduction: Space travel imposes significant gravitational and radiation stress on both
cellular and systemic physiology, resulting in myriad cardiovascular changes that have not …

Bioprinting of cardiac tissue in space: Where are we?

K Tabury, E Rehnberg, B Baselet… - Advanced …, 2023 - Wiley Online Library
Bioprinting in space is the next frontier in tissue engineering. In the absence of gravity, novel
opportunities arise, as well as new challenges. The cardiovascular system needs particular …

Safeguarding Earth's biodiversity by creating a lunar biorepository

M Hagedorn, LR Parenti, RA Craddock… - …, 2024 - academic.oup.com
Earth's biodiversity is increasingly threatened and at risk. We propose a passive lunar
biorepository for long-term storage of prioritized taxa of live cryopreserved samples to …

Spaceflight alters protein levels and gene expression associated with stress response and metabolic characteristics in human cardiac spheroids

P Forghani, W Liu, Z Wang, Z Ling, F Takaesu, E Yang… - Biomaterials, 2025 - Elsevier
Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) possess
tremendous advantage for cardiac regeneration. However, cell survival is challenging upon …

Cardiovascular diseases in spaceflight

B Baselet, S Miranda, E Rehnberg… - Precision Medicine for …, 2025 - Elsevier
Spaceflight and prolonged exposure to microgravity and radiation significantly impact
human cardiovascular physiology, both in the short and long term. Astronauts experience …