[HTML][HTML] Single cell cancer epigenetics
M Casado-Pelaez, A Bueno-Costa, M Esteller - Trends in Cancer, 2022 - cell.com
Bulk sequencing methodologies have allowed us to make great progress in cancer
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic …
Epigenomic heterogeneity as a source of tumour evolution
In the past decade, remarkable progress in cancer medicine has been achieved by the
development of treatments that target DNA sequence variants. However, a purely genetic …
development of treatments that target DNA sequence variants. However, a purely genetic …
Map** spatial organization and genetic cell-state regulators to target immune evasion in ovarian cancer
The drivers of immune evasion are not entirely clear, limiting the success of cancer
immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to …
immunotherapies. Here we applied single-cell spatial and perturbational transcriptomics to …
Single-cell transcriptome profiles the heterogeneity of tumor cells and microenvironments for different pathological endometrial cancer and identifies specific sensitive …
F Ren, L Wang, Y Wang, J Wang, Y Wang… - Cell Death & …, 2024 - nature.com
Endometrial cancer (EC) is a highly heterogeneous malignancy characterized by varied
pathology and prognoses, and the heterogeneity of its cancer cells and the tumor …
pathology and prognoses, and the heterogeneity of its cancer cells and the tumor …
Multiparameter single-cell proteomic technologies give new insights into the biology of ovarian tumors
IG Funingana, JS Bedia, YW Huang… - Seminars in …, 2023 - Springer
High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy. Its
diagnosis at advanced stage compounded with its excessive genomic and cellular …
diagnosis at advanced stage compounded with its excessive genomic and cellular …
A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing
As part of the Human Cell Atlas Initiative, our goal is to generate single-cell transcriptomics
(single-cell RNA sequencing [scRNA-seq], 86,708 cells) and regulatory (single-cell assay on …
(single-cell RNA sequencing [scRNA-seq], 86,708 cells) and regulatory (single-cell assay on …
A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer
MR Kelly, K Wisniewska, MJ Regner, MW Lewis… - Nature …, 2022 - nature.com
The human genome contains regulatory elements, such as enhancers, that are often rewired
by cancer cells for the activation of genes that promote tumorigenesis and resistance to …
by cancer cells for the activation of genes that promote tumorigenesis and resistance to …
Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells
SH Sinno, JA Imperatore, S Bai… - The Journal of Clinical …, 2024 - jci.org
Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs)
play a critical role in resistance to immunotherapy. In this study, we identified epidermal …
play a critical role in resistance to immunotherapy. In this study, we identified epidermal …