Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute
respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

The goal is to provide an extensive review of the physiologic role of thrombomodulin (TM) in
maintaining vascular homeostasis, with a focus on its anti-inflammatory properties. Data …

The ability of the lung to perform gas exchange is made possible in part by the effective
relationship between the alveolar epithelium and the endothelium of the pulmonary …

Background Sepsis remains a common and serious condition with significant morbidity and
mortality due to multiple organ dysfunction, especially acute lung injury (ALI) and acute …

Treatment of injured donor lungs ex vivo to accelerate organ recovery and ameliorate
reperfusion injury could have a major impact in lung transplantation. We have recently …

Oxygen (O2) is life essential but as a drug has a maximum positive biological benefit and
accompanying toxicity effects. Oxygen is therapeutic for treatment of hypoxemia and hypoxia …

ABSTRACT SARS-CoV-2 causes COVID-19, an acute respiratory distress syndrome
(ARDS) characterized by pulmonary edema, viral pneumonia, multiorgan dysfunction …

Thrombomodulin (TM), a widely expressing glycoprotein originally identified in vascular
endothelium, is an important cofactor in the protein C anticoagulant system. TM appears to …

There is compelling evidence that uncontrolled activation of the coagulation cascade
following lung injury contributes to the development of lung inflammation and fibrosis in …