Synaptic dysfunction is closely related to Alzheimer's disease (AD) which is also recognized
as synaptic disorder. β-amyloid (Aβ) is one of the main pathogenic factors in AD, which …

Alzheimer's disease (AD) is known as the most fatal chronic neurodegenerative disease in
adults along with progressive loss of memory and other cognitive function disorders. Cyclin …

It is estimated that Alzheimer's disease (AD) affects tens of millions of people, comprising not
only suffering patients, but also their relatives and caregivers. AD is one of age-related …

The early stages of Alzheimer's disease are characterised by impaired synaptic plasticity
and synapse loss. Here, we show that amyloid-β oligomers (AβOs) activate the c-Abl kinase …

Alzheimer's disease (AD) is characterized by progressive memory loss and dementia. The
strong correlation between cognitive decline and the loss of synapses supports the idea that …

Cyclin-dependent kinase-5 (Cdk5) was reported to downscale neurotransmission by
sequestering synaptic vesicles (SVs) in the release-reluctant resting pool, but the molecular …

Neurons are highly compartmentalized cells with tightly controlled subcellular protein
organization. While brain transcriptome, connectome and global proteome maps are being …

At synapses, pre-and post-synaptic cells get in direct contact with each other via cell
adhesion molecules (CAMs). Several CAMs have been identified at the neuromuscular …

In the brain, the connection between sensory information triggered by the presence of a
stressor and the organism's reaction involves limbic areas such as the hippocampus …

The epigenome is uniquely positioned as a point of convergence, integrating multiple
intracellular signaling cascades into a cohesive gene expression profile necessary for long …