Biomolecular condensates are two-and three-dimensional compartments in eukaryotic cells
that concentrate specific collections of molecules without an encapsulating membrane …

Emerging clinical evidence shows that the deregulation of ubiquitin-mediated degradation of
oncogene products or tumour suppressors is likely to be involved in the aetiology of …

Constitutive activation of the FLT3 receptor tyrosine kinase, either by internal tandem
duplication (ITD) of the juxtamembrane region or by point mutations in the second tyrosine …

A functional genomic approach, based on systematic data gathering, was used to
characterize a family of proteins containing a tri partite m otif (TRIM). A total of 37 TRIM …

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear
body (PML-NB) and is crucially required for the proper assembly of this macromolecular …

DNA damage frequently triggers death by apoptosis. The irreversible decision to die can be
facilitated or forestalled through integration of a wide variety of stimuli from within and …

The tumour suppressor p53 induces cellular senescence in response to oncogenic signals.
p53 activity is modulated by protein stability and post-translational modification, including …

PML nuclear bodies are matrix-associated domains that recruit an astonishing variety of
seemingly unrelated proteins. Since their discovery in the early 1960s, PML bodies have …

Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO regulates
various cellular processes, such as nuclear transport, signal transduction, stress response …

Acetylation of lysine residues is a post-translational modification with broad relevance to
cellular signalling and disease biology. Enzymes that 'write'(histone acetyltransferases …