[HTML][HTML] Oxidative cysteine post translational modifications drive the redox code underlying neurodegeneration and amyotrophic lateral sclerosis

A Percio, M Cicchinelli, D Masci, M Summo, A Urbani… - Antioxidants, 2024 - mdpi.com
Redox dysregulation, an imbalance between oxidants and antioxidants, is crucial in the
pathogenesis of various neurodegenerative diseases. Within this context, the “redoxome” …

Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration

S Zafar, SI Fatima, M Schmitz, I Zerr - Biomolecules, 2024 - mdpi.com
Neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and
Huntington's disease, are identified and characterized by the progressive loss of neurons …

Neuroinflammation at the crossroads of metabolic and neurodegenerative diseases: Causes, consequences and interventions.

R Pathak, S Sharma, M Bhandari… - Journal of …, 2024 - search.ebscohost.com
Neuroinflammation is increasingly recognized as a pivotal factor not only in
neurodegenerative diseases such as Alzheimer's and Parkinson's, but also in the …

Exploring Natural Compounds as Potential CDK4 Inhibitors for Therapeutic Intervention in Neurodegenerative Diseases through Computational Analysis

N Rani, P Kumar - Molecular Biotechnology, 2024 - Springer
CDK4 is a member of the serine-threonine kinase family, which has been found to be
overexpressed in a plethora of studies related to neurodegenerative diseases. CDK4 is one …

PTMs of PD-1/PD-L1 and PROTACs application for improving cancer immunotherapy

X Ren, L Wang, L Liu, J Liu - Frontiers in Immunology, 2024 - frontiersin.org
Immunotherapy has been developed, which harnesses and enhances the innate powers of
the immune system to fight disease, particularly cancer. PD-1 (programmed death-1) and PD …

The main sources of molecular organization in the cell. Atlas of self-organized and self-regulated dynamic biostructures

M Ildefonso, JM Cortes, I Malaina… - Progress in Biophysics …, 2025 - Elsevier
One of the most important goals of contemporary biology is to understand the principles of
the molecular order underlying the complex dynamic architecture of cells. Here, we present …

[HTML][HTML] O-GlcNAcylation in ovarian tumorigenesis and its therapeutic implications

L **a, J Mei, M Huang, D Bao, Z Wang, Y Chen - Translational Oncology, 2025 - Elsevier
Ovarian cancer is a prevalent malignancy among women, often associated with a poor
prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been …

A Comprehensive Review on Molecular Mechanisms, Treatments, and Brief Role of Natural Products in Hepatocellular Cancer

L Jiang, Q Meng, L Liu, W Li - Natural Product …, 2024 - journals.sagepub.com
Most initial liver cancers are hepatocellular carcinomas (HCC), which make up the vast
majority of cases. Hepatitis B or C virus infection as well as alcohol consumption is among …

[PDF][PDF] Pazopanib: Effective monotherapy for precise cancer treatment, targeting specific mutations and tumors

R Pathak, V Kaur, S Sharma, M Bhandari, R Mishra… - Cancer, 2024 - researchgate.net
Cancer is a wide range of illnesses characterized by the expansion of abnormal cells with
the ability to invade and damage healthy bodily tissue. Cancer is treated with a variety of …

Histone methylation and acetylation in cancer: mechanism, progression, and targets

S Bu, T Ye, H Gao, H Song, Y Zhu - Oncologie, 2024 - degruyter.com
Along with the continuous development of chromatin immunoprecipitation sequencing and
its derivative technologies, as well as an increased understanding of epigenetic …