▪ Abstract Chemokines compose a sophisticated communication system used by all our cell
types, including immune cells. Chemokine messages are decoded by specific receptors that …

Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation.
The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is …

As few as one in 100,000 B and T lymphocytes are specific for a single protein antigen, such
as tetanus toxin, yet these cells must come together if an antibody response is to occur …

Biomolecule gradients have been shown to play roles in a wide range of biological
processes including development, inflammation, wound healing, and cancer metastasis …

G‐protein–coupled receptor (GPCR) signaling is essential for the spatiotemporal control of
leukocyte dynamics during immune responses. For efficient navigation through mammalian …

Neutrophils must follow both endogenous and bacterial chemoattractant signals out of the
vasculature and through the interstitium to arrive at a site of infection. By necessity, in the …

Since their discovery 13 years ago, chemokines have emerged as the most important
regulators of leukocyte trafficking. On target cells, chemokines bind to seven-transmembrane …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

Eukaryotic cells can detect shallow gradients of chemoattractants with exquisite precision
and respond quickly to changes in the gradient steepness and direction. Here, we describe …

Neutrophil migration to sites of inflammation and the subsequent execution of multiple
functions are designed to contain and kill invading pathogens. These highly regulated and …