The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …

Alterations in the regulation of gene expression are frequently associated with
developmental diseases or cancer. Transcription activation is a key phenomenon in the …

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly
mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal …

Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

Transcription in several organisms from certain bacteria to humans has been observed to be
stochastic in nature: toggling between active and inactive states. Periods of active nascent …

The packaging of DNA into strings of nucleosomes is one of the features that allows
eukaryotic cells to tightly regulate gene expression. The ordered disassembly of …

Most histones are assembled into nucleosomes behind the replication fork to package newly
synthesized DNA. By contrast, histone variants, which are encoded by separate genes, are …

We describe a Hi-C-based method, Micro-C, in which micrococcal nuclease is used instead
of restriction enzymes to fragment chromatin, enabling nucleosome resolution chromosome …

Nucleosomes are efficient DNA-packaging units. The fundamental protein unit of the
nucleosome is the histone dimer, a simple α-helical domain possessing a highly basic …

The accurate and complete replication of genomic DNA is essential for all life. In eukaryotic
cells, the assembly of the multi-enzyme replisomes that perform replication is divided into …