Antiviral actions of interferons
CE Samuel - Clinical microbiology reviews, 2001 - Am Soc Microbiol
Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …
Innate host defense mechanisms of fish against viruses and bacteria
AE Ellis - Developmental & Comparative Immunology, 2001 - Elsevier
The integumental defenses provide a physical and chemical barrier to the attachment and
penetration of microbes. Besides the entrap** and sloughing of microbes in the mucus …
penetration of microbes. Besides the entrap** and sloughing of microbes in the mucus …
Noncytolytic control of viral infections by the innate and adaptive immuneresponse
This review describes the contribution of noncytolytic mechanisms to the control of viral
infections with a particular emphasis on the role of cytokines in these processes. It has long …
infections with a particular emphasis on the role of cytokines in these processes. It has long …
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
MA Garcia, J Gil, I Ventoso, S Guerra… - Microbiology and …, 2006 - Am Soc Microbiol
The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …
Inhibition of viral replication by interferon-γ-induced nitric oxide synthase
Interferons (IFNs) induce antiviral activity in many cell types. The ability of IFN-γ to inhibit
replication of ectromelia, vaccinia, and herpes simplex-1 viruses in mouse macrophages …
replication of ectromelia, vaccinia, and herpes simplex-1 viruses in mouse macrophages …
The dsRNA protein kinase PKR: virus and cell control
The IFN-induced double-stranded RNA-dependent protein kinase (PKR) is one of the four
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …
mammalian serine-threonine kinases (the three others being HRI, GCN2 and PERK) that …
Pathogenesis of hepatitis B virus infection
FV Chisari, M Isogawa, SF Wieland - Pathologie Biologie, 2010 - Elsevier
The adaptive immune response is thought to be responsible for viral clearance and disease
pathogenesis during hepatitis B virus infection. It is generally acknowledged that the …
pathogenesis during hepatitis B virus infection. It is generally acknowledged that the …
Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase
JB Patterson, CE Samuel - Molecular and cellular biology, 1995 - Taylor & Francis
A 6,474-nucleotide human cDNA clone designated K88, which encodes double-stranded
RNA (dsRNA)-specific adenosine deaminase, was isolated in a screen for interferon (IFN) …
RNA (dsRNA)-specific adenosine deaminase, was isolated in a screen for interferon (IFN) …
Interactions between double-stranded RNA regulators and the protein kinase DAI
L Manche, SR Green, C Schmedt… - Molecular and cellular …, 1992 - Taylor & Francis
The interferon-induced protein kinase DAI, the double-stranded RNA (dsRNA)-activated
inhibitor of translation, plays a key role in regulating protein synthesis in higher cells. Once …
inhibitor of translation, plays a key role in regulating protein synthesis in higher cells. Once …
Evidence for antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication.
KD Croen - The Journal of clinical investigation, 1993 - Am Soc Clin Investig
Nitric oxide (NO) has antimicrobial activity against a wide spectrum of infectious pathogens,
but an antiviral effect has not been reported. The impact of NO, from endogenous and …
but an antiviral effect has not been reported. The impact of NO, from endogenous and …