Transcriptional regulation is a critical adaptive mechanism that allows bacteria to respond to
changing environments, yet the concept of transcriptional plasticity (TP)–the variability of …

End-to-end RNA-sequencing methods that capture 5′-sequence content without
cumbersome library manipulations are of great interest, particularly for analysis of long …

Drug-resistant bacteria are emerging as a global threat, despite frequently being less fit than
their drug-susceptible ancestors,,,,,,–. Here we sought to define the mechanisms that drive or …

In many bacteria, the essential factors Rho and NusG mediate termination of synthesis of
nascent transcripts (including antisense RNAs) which are not being simultaneously …

RNA molecules play important roles in numerous normal cellular processes and disease
states, from protein coding to gene regulation. RT-PCR, applying the power of polymerase …

In mycobacteria, regulation of transcript degradation is known to occur in response to
environmental stress and to facilitate adaptation. However, the mechanisms underlying this …

Background: The global rate of antimicrobial resistance is rising for M. tuberculosis, the
leading causative agent of tuberculosis infections. Gold standard phenotypic methods for …

The growing research on antisense transcription has revealed the importance of cellular
function in gene regulation. As the prevalent, unappreciative regard of the non-coding strand …

The central dogma elucidates the process by which genetic information is transferred from
DNA to RNA and ultimately to protein. During transcription, messenger RNA (mRNA) is …

中心法则描述了遗传信息从DNA 到RNA 再到蛋白质的传递过程. 转录过程是RNA
聚合酶以DNA 为模板合成信使RNA 的过程, 翻译过程是核糖体利用信使RNA …