Conquering the host: determinants of pathogenesis learned from murine gammaherpesvirus 68

Y Wang, SA Tibbetts, LT Krug - Annual review of virology, 2021 - annualreviews.org
Gammaherpesviruses are an important class of oncogenic pathogens that are exquisitely
evolved to their respective hosts. As such, the human gammaherpesviruses Epstein-Barr …

Helminth-induced IL-4 expands bystander memory CD8+ T cells for early control of viral infection

M Rolot, AM Dougall, A Chetty, J Javaux… - Nature …, 2018 - nature.com
Infection with parasitic helminths can imprint the immune system to modulate bystander
inflammatory processes. Bystander or virtual memory CD8+ T cells (TVM) are non …

Cytomegalovirus host entry and spread

HE Farrell, PG Stevenson - Journal of General Virology, 2019 - microbiologyresearch.org
Cytomegaloviruses (CMVs) are large, complex pathogens that persistently and systemically
colonize most mammals. Human cytomegalovirus (HCMV) causes congenital harm, and has …

Murine cytomegalovirus exploits olfaction to enter new hosts

HE Farrell, C Lawler, CSE Tan, K MacDonald, K Bruce… - MBio, 2016 - journals.asm.org
Viruses transmit via the environmental and social interactions of their hosts. Herpesviruses
have colonized mammals since their earliest origins, suggesting that they exploit ancient …

Rational development of an attenuated recombinant cyprinid herpesvirus 3 vaccine using prokaryotic mutagenesis and in vivo bioluminescent imaging

M Boutier, M Ronsmans, P Ouyang, G Fournier… - PLoS …, 2015 - journals.plos.org
Cyprinid herpesvirus 3 (CyHV-3) is causing severe economic losses worldwide in common
and koi carp industries, and a safe and efficacious attenuated vaccine compatible with mass …

Herpes simplex virus 1 targets the murine olfactory neuroepithelium for host entry

M Shivkumar, R Milho, JS May, MP Nicoll… - Journal of …, 2013 - journals.asm.org
ABSTRACT Herpes simplex virus 1 (HSV-1) is a ubiquitous and important human pathogen.
It is known to persist in trigeminal ganglia (TG), but how it reaches this site has been difficult …

A murid gamma-herpesviruses exploits normal splenic immune communication routes for systemic spread

B Frederico, B Chao, JS May, GT Belz, PG Stevenson - Cell host & microbe, 2014 - cell.com
Gamma-herpesviruses (γHVs) are widespread oncogenic pathogens that chronically infect
circulating lymphocytes. How they subvert the immune check-point function of the spleen to …

Host entry by gamma-herpesviruses—lessons from animal viruses?

L Gillet, B Frederico, PG Stevenson - Current opinion in virology, 2015 - Elsevier
Highlights•There is no good evidence for oral gammaherpesvirus entry.•Animal viruses can
help us to decipher their human counterparts.•MuHV-4 enters new hosts via the olfactory …

Tissue and cellular tropism of Eptesicus fuscus gammaherpesvirus in big brown bats, potential role of pulmonary intravascular macrophages

UG Perdrizet, JE Hill, LR Sobchishin… - Veterinary …, 2024 - journals.sagepub.com
Gammaherpesviruses (γHVs) are recognized as important pathogens in humans but their
relationship with other animal hosts, especially wildlife species, is less well characterized …

A role of hypoxia-inducible factor 1 alpha in Murine Gammaherpesvirus 68 (MHV68) lytic replication and reactivation from latency

DM López-Rodríguez, V Kirillov, LT Krug… - PLoS …, 2019 - journals.plos.org
The hypoxia-inducible factor 1 alpha (HIF1α) protein and the hypoxic microenvironment are
critical for infection and pathogenesis by the oncogenic gammaherpesviruses (γHV), Kaposi …