Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Biophotonics as a highly interdisciplinary frontier often requires the assistance of optical
agents to control the light pathways in cells, tissues and living organisms for specific …

Hypoxia development in tumor is closely associated with its increased aggressiveness and
strong resistance to therapy, leading to the poor prognosis in several cancer types …

In an era of personalized medicine, the clinical community has become increasingly focused
on understanding diseases at the cellular and molecular levels. Magnetic resonance …

Trivalent lanthanide ions offer remarkable opportunities in the design of bioimaging agents:
this review presents an accessible discussion of their application in both optical and …

Positron emission tomography (PET) is an important driver for present day healthcare.
Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview …

Pretargeted imaging has emerged as a promising approach to advance nuclear imaging of
malignant tumors. Herein, we combine the enzyme‐mediated fluorogenic reaction and in …

This review focuses on MRI contrast agents that are responsive to a change in a
physiological biomarker. The response mechanisms are dependent on six physicochemical …

Over the last twenty-five years 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid
(DOTA) has made a significant impact on the field of diagnostic imaging. DOTA is not the …

Bifunctional chelating agents (BFCAs) are molecules which contain two different moieties: a
strong metal chelating unit and a reactive functional group. The latter is directed to react with …