i-Motif DNA: identification, formation, and cellular functions

S Tao, Y Run, D Monchaud, W Zhang - Trends in Genetics, 2024 - Elsevier
An i-motif (iM) is a four-stranded (quadruplex) DNA structure that folds from cytosine (C)-rich
sequences. iMs can fold under many different conditions in vitro, which paves the way for …

iMab antibody binds single-stranded cytosine-rich sequences and unfolds DNA i-motifs

J Boissieras, H Bonnet, MF Susanto… - Nucleic Acids …, 2024 - academic.oup.com
Abstract i-Motifs (iMs) are non-canonical, four-stranded secondary structures formed by
stacking of hemi-protonated CH+· C base pairs in cytosine-rich DNA sequences …

i-Motifs as Regulatory Switches: Mechanisms and Implications for Gene Expression

A Deep, A Bhat, V Perumal, S Kumar - Molecular Therapy Nucleic Acids, 2025 - cell.com
Abstract i-Motifs, cytosine-tetrads or C-quadruplexes, are intercalated structures formed by
base pairing between cytosine and protonated cytosine. These structures demonstrate …

Shedding Light on the Photophysics and Photochemistry of I-Motifs Using Quantum Mechanical Calculations

R Improta - International Journal of Molecular Sciences, 2023 - mdpi.com
I-motifs are non-canonical DNA structures formed by intercalated hemiprotonated (CH· C)+
pairs, ie, formed by a cytosine (C) and a protonated cytosine (CH+), which are currently …

Genomic Instability of G-Quadruplex Sequences in Escherichia coli: Roles of DinG, RecG, and RecQ Helicases

VJ Parekh, G Węgrzyn, V Arluison, RR Sinden - Genes, 2023 - mdpi.com
Guanine-rich DNA can fold into highly stable four-stranded DNA structures called G-
quadruplexes (G4). Originally identified in sequences from telomeres and oncogene …

Nanopore-based single-molecule investigation of the effects of anthracycline anticancer drugs on i-motif

Z Wang, L Liu, Z Li, L Li, X Liu, R Cui, F Yao, L Tian… - Microchemical …, 2025 - Elsevier
Intercalated binding of anthracycline anticancer drugs to DNA is associated with anticancer
mechanisms. The i-motif, a cytosine-rich DNA secondary structure found in the promoter …

Spotlight on G-Quadruplexes: From Structure and Modulation to Physiological and Pathological Roles

MC Dell'Oca, R Quadri, GM Bernini, L Menin… - International Journal of …, 2024 - mdpi.com
G-quadruplexes or G4s are non-canonical secondary structures of nucleic acids
characterized by guanines arranged in stacked tetraplex arrays. Decades of research into …

[HTML][HTML] Insights into the Molecular Structure, Stability, and Biological Significance of Non-Canonical DNA Forms, with a Focus on G-Quadruplexes and i-Motifs

P Obara, P Wolski, T Pańczyk - Molecules, 2024 - pmc.ncbi.nlm.nih.gov
This article provides a comprehensive examination of non-canonical DNA structures,
particularly focusing on G-quadruplexes (G4s) and i-motifs. G-quadruplexes, four-stranded …

[HTML][HTML] Exploring i-Motif DNA binding with benzothiazolino Coumarins: Synthesis, Screening, and spectroscopic insights

S Bag, K Chand, MD Burman, S Vertueux, E Chorell… - Bioorganic …, 2025 - Elsevier
I-motif (iM) DNA structures are dynamic cytosine-rich secondary structures that are
increasingly recognized for their roles in transcriptional regulation, genomic stability, and for …

[HTML][HTML] Синтез и биологические свойства малых молекул—лигандов неканонических структур ДНК и РНК

МС Абрамович, ПВ Заикина, ЕС Барская… - Russian Chemical …, 2024 - uspkhim.ru
Аннотация Нуклеиновые кислоты являются важными мишенями для многих
противоопухолевых препаратов. Помимо канонической двухцепочечной В-спирали …