Can testing predict SARS-CoV-2 infectivity? The potential for certain methods to be surrogates for replication-competent virus

MJ Binnicker - Journal of clinical microbiology, 2021 - Am Soc Microbiol
Since the beginning of the COVID-19 pandemic, molecular methods (eg, real-time PCR)
have been the primary means of diagnosing the disease. It is now well established that …

Daily longitudinal sampling of SARS-CoV-2 infection reveals substantial heterogeneity in infectiousness

R Ke, PP Martinez, RL Smith, LL Gibson, A Mirza… - Nature …, 2022 - nature.com
The dynamics of SARS-CoV-2 replication and shedding in humans remain poorly
understood. We captured the dynamics of infectious virus and viral RNA shedding during …

[HTML][HTML] Performance of an antigen-based test for asymptomatic and symptomatic SARS-CoV-2 testing at two university campuses—Wisconsin, September–October …

IW Pray - MMWR. Morbidity and mortality weekly report, 2021 - cdc.gov
Compared with real-time reverse transcription–polymerase chain reaction (RT-PCR) testing,
the Sofia antigen test had a sensitivity of 80.0% and specificity of 98.9% among symptomatic …

The displacement of the SARS-CoV-2 variant Delta with Omicron: An investigation of hospital admissions and upper respiratory viral loads

A Fall, RE Eldesouki, J Sachithanandham, CP Morris… - …, 2022 - thelancet.com
Background The increase in SARS-CoV-2 infections in December 2021 was driven primarily
by the Omicron variant, which largely displaced the Delta over a three-week span. Outcomes …

[HTML][HTML] Infection with the SARS-CoV-2 delta variant is associated with higher infectious virus loads compared to the alpha variant in both unvaccinated and …

CH Luo, CP Morris, J Sachithanandham, A Amadi… - MedRxiv, 2021 - ncbi.nlm.nih.gov
Background The emerging SARS-CoV-2 variant of concern (VOC) B. 1.6. 17.2 (Delta)
quickly displaced the B. 1.1. 7 (Alpha) and is associated with increases in COVID-19 cases …

Increased viral variants in children and young adults with impaired humoral immunity and persistent SARS-CoV-2 infection: a consecutive case series

TT Truong, A Ryutov, U Pandey, R Yee, L Goldberg… - …, 2021 - thelancet.com
Background There is increasing concern that persistent infection of SARS-CoV-2 within
immunocompromised hosts could serve as a reservoir for mutation accumulation and …

Decreased infectivity following BNT162b2 vaccination: a prospective cohort study in Israel

G Regev-Yochay, S Amit, M Bergwerk… - The Lancet Regional …, 2021 - thelancet.com
Background BNT162b2 was shown to be 92% effective in preventing COVID-19. Prioritizing
vaccine rollout, and achievement of herd immunity depend on SARS-CoV-2 transmission …

Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice

AA Ordonez, CK Bullen, AF Villabona-Rueda… - Communications …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the cause of
coronavirus disease 2019 (COVID-19), has incited a global health crisis. Currently, there are …

Understanding the outcomes of COVID-19–does the current model of an acute respiratory infection really fit?

P Simmonds, S Williams… - Journal of General …, 2021 - microbiologyresearch.org
Although coronavirus disease 2019 (COVID-19) is regarded as an acute, resolving infection
followed by the development of protective immunity, recent systematic literature review …

Same-day SARS-CoV-2 antigen test screening in an indoor mass-gathering live music event: a randomised controlled trial

B Revollo, I Blanco, P Soler, J Toro… - The Lancet Infectious …, 2021 - thelancet.com
Background The banning of mass-gathering indoor events to prevent SARS-CoV-2 spread
has had an important effect on local economies. Despite growing evidence on the suitability …