Metabolic engineering aims to maximize the production of bio-economically important
substances (compounds, enzymes, or other proteins) through the optimization of the …

Food security has become a pressing issue in the modern world. The ever-increasing world
population, ongoing COVID-19 pandemic, and political conflicts together with climate …

Innate immune cells recognize pathogens through pattern recognition receptors (PRRs),
and activation of PRRs induces downstream signaling pathways to mount appropriate …

TLR3 recognizes dsRNAs and is considered of key importance to antiviral host-defense
responses. TLR3 also triggers neuroprotective responses in astrocytes and controls the …

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and
stimulate the innate immune response through the production of cytokines. The innate …

Highlights•Microorganism-based alternative food holds great potential for addressing future
food security challenges.•Significant challenges remain due to the highly reductionist nature …

Background Tumor necrosis factor (TNF) is a widely studied cytokine (ligand) that induces
proinflammatory signaling and regulates myriad cellular processes. In major illnesses, such …

The majority of human genome are non-coding genes. Recent research have revealed that
about half of these genome sequences make up of transposable elements (TEs). A branch …

This perspective outlines an approach to improve mechanistic understanding of
macrophages in inflammation and tissue homeostasis, with a focus on human inflammatory …

Over the last decade, our research team has investigated the dynamic responses and global
properties of living cells using systems biology approaches. More specifically, we have …