Spermatogenesis is the cellular process by which spermatogonia develop into mature
spermatids within seminiferous tubules, the functional unit of the mammalian testis, under …

The programmed death protein 1 (PD-1) and its ligand (PD-L1) represent a well-
characterized immune checkpoint in cancer, effectively targeted by monoclonal antibodies …

Cancer cells exploit the expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) to
subvert T-cell-mediated immunosurveillance,. The success of therapies that disrupt PD-L1 …

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining
proper neural homeostasis and protecting the neural tissue from potential blood borne …

The dysregulated expression of immune checkpoint molecules enables cancer cells to
evade immune destruction. While blockade of inhibitory immune checkpoints like PD-L1 …

Tight junctions are complex supramolecular entities composed of integral membrane
proteins, membrane-associated and soluble cytoplasmic proteins engaging in an intricate …

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal ailments among
those seeking health care for gastrointestinal disorders. Despite its prevalence, IBS …

Immune cell-specific expression is one indication of the importance of a gene's role in the
immune response. We have compiled a compendium of microarray expression data for …

In vitro studies have demonstrated that occludin and tricellulin are important for tight junction
barrier function, but in vivo data suggest that loss of these proteins can be overcome. The …

Belt-like tight junctions (TJs), referred to as zonula occludens, have long been regarded as a
specialized differentiation of epithelial cell membranes. They are required for cell adhesion …