Seizures result from hypersynchronous, abnormal firing of neuronal populations and are the
primary clinical symptom of the epilepsies. Brain tissue from animal models and patients …

Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …

Surgical removal of the epileptogenic zone provides an effective therapy for several focal
epileptic syndromes. This surgery offers the opportunity to study pathological activity in living …

Serotonin type 7 receptors (5-HT7) are expressed in several brain areas, regulate brain
development, synaptic transmission and plasticity, and therefore are involved in various …

Epilepsy is a common brain disorder characterized by the occurrence of spontaneous
seizures. These bursts of synchronous firing arise from abnormalities of neuronal networks …

Ion channel dysfunction or “channelopathy” is a proven cause of epilepsy in the relatively
uncommon genetic epilepsies with Mendelian inheritance. But numerous examples of …

The dentate gyrus (DG), the input gate to the hippocampus proper, is anatomically
segregated into three different sectors, namely, the suprapyramidal blade, the crest region …

Cannabidiol (CBD) is a naturally occurring compound found in the Cannabis plant that is
known for its potential therapeutic effects. However, its impact on membrane ionic currents …

Degeneracy, the ability of multiple structural components to elicit the same characteristic
functional properties, constitutes an elegant mechanism for achieving biological robustness …