Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The sirtuins (SIRTs; of which there are seven in mammals) are NAD+-dependent enzymes
that regulate a large number of cellular pathways and forestall the progression of ageing …

SIRT6, a member of the SIRT deacetylase family, is responsible for deacetylation of histone
H3 N ε-acetyl-lysines 9 (H3K9ac) and 56 (H3K56ac). As a tumor suppressor, SIRT6 has …

Acetyl-CoA, as an important molecule, not only participates in multiple intracellular
metabolic reactions, but also affects the post-translational modification of proteins, playing a …

Mammalian sirtuins have emerged in recent years as critical modulators of multiple
biological processes, regulating cellular metabolism, DNA repair, gene expression, and …

Exploiting cancer metabolism for the clinical benefit of patients with hepatocellular
carcinoma (HCC) is a topic under active investigation. Ubiquitin-specific peptidase 48 …

Cancer is a disease characterized by unrestrained cellular proliferation. In order to sustain
growth, cancer cells undergo a complex metabolic rearrangement characterized by changes …

The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …

SIRT6, a member of the Sirtuin family of NAD+-dependent enzymes, has established roles in
chromatin signaling and genome maintenance. Through these functions, SIRT6 protects …

SIRT6 and COX-2 are oncogenes target that promote the expression of proinflammatory and
pro-survival proteins through a signaling pathway, which leads to increased survival and …