The ichthyoses are a large, heterogeneous group of skin cornification disorders. They can
be inherited or acquired, and result in defective keratinocyte differentiation and abnormal …

The discovery in 2006 that loss-of-function mutations in the filaggrin gene (FLG) cause
ichthyosis vulgaris and can predispose to atopic dermatitis (AD) galvanized the dermatology …

There is a lack of high-quality evidence based on the gold standard of oral food challenges
to determine food allergy prevalence. Nevertheless, studies using surrogate measures of …

Objective To provide an overview of filaggrin biology and the role of filaggrin variants in
atopic dermatitis (AD) and allergic disease. Data Sources We performed a PubMed literature …

Whole metagenome analysis has the potential to reveal functional triggers of skin diseases,
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …

Objective To summarize studies investigating ethnical and racial differences in atopic
dermatitis (AD) epidemiology, clinical features, and skin and blood phenotypes. Data …

Background Previous studies found conflicting results about the commonality of different
atopic dermatitis (AD) signs and symptoms. Objective To determine the prevalences of AD …

Filaggrin Mutations Associated with Skin and Allergic Diseases | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Atopic dermatitis (AD) is driven by a complex gene–environment interaction. Many of the risk
factors and genetic underpinning previously observed for pediatric AD may not apply to …

A hallmark of atopic eczema (AE) is skin barrier dysfunction. Lipids in the stratum corneum
(SC), primarily ceramides, fatty acids, and cholesterol, are crucial for the barrier function, but …