Efforts to expand the genetic alphabet are predicated upon a stable and replicable third
base pair. Recent progress has resulted in the development of several candidates that are …

DNA damage by chemicals, radiation, or oxidative stress leads to a mutational spectrum,
which is complex because it is determined in part by lesion structure, the DNA sequence …

Artificially expanded genetic information systems (AEGISs) are unnatural forms of DNA that
increase the number of independently replicating nucleotide building blocks. To do this …

The structure, function and reactions of nucleic acids are central to molecular biology and
are crucial for the understanding of complex biological processes involved. Revised and …

Axiomatically, the density of information stored in DNA, with just four nucleotides (GACT), is
higher than in a binary code, but less than it might be if synthetic biologists succeed in …

The next goals in the development of a synthetic biology that uses artificial genetic systems
will require chemistry–biology combinations that allow the amplification of DNA containing …

Toward the expansion of the genetic alphabet, we present an unnatural base pair system for
efficient PCR amplification, enabling the site-specific incorporation of extra functional …

Single-stranded DNA genomes have been constructed that site-specifically contain the 7, 8-
dihydro-8-oxo-2 '-deoxyguanine (8-oxoG) oxidation products guanidinohydantoin (Gh) and …

Attesting to the spectacular growth in the field of structural biology, the total number of
coordinate files deposited in the Protein Data Bank was rapidly approaching 30 000 entries …

In this article, we focus on the synthesis of aryl C-glycosides via Heck coupling. It is
organized based on the type of structures used in the assembly of the C-glycosides (also …