Post-translational regulation of inflammasomes
Inflammasomes play essential roles in immune protection against microbial infections.
However, excessive inflammation is implicated in various human diseases, including …
However, excessive inflammation is implicated in various human diseases, including …
Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases
A Salminen, J Ojala, K Kaarniranta… - Cellular and Molecular …, 2012 - Springer
Oxidative stress and low-grade inflammation are the hallmarks of the aging process and are
even more enhanced in many age-related degenerative diseases. Mitochondrial dysfunction …
even more enhanced in many age-related degenerative diseases. Mitochondrial dysfunction …
TLR activation regulates damage‐associated molecular pattern isoforms released during pyroptosis
Infection of macrophages by bacterial pathogens can trigger Toll‐like receptor (TLR)
activation as well as Nod‐like receptors (NLRs) leading to inflammasome formation and cell …
activation as well as Nod‐like receptors (NLRs) leading to inflammasome formation and cell …
Inflammasomes of the intestinal epithelium
While the functional importance of inflammasomes in blood-derived cell types is well
established, it remains poorly understood how inflammasomes in nonhematopoietic cells …
established, it remains poorly understood how inflammasomes in nonhematopoietic cells …
NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production
VM Gonçalves, KC Matteucci, CL Buzzo… - PLoS neglected …, 2013 - journals.plos.org
Trypanosoma cruzi (T. cruzi) is an intracellular protozoan parasite and the etiological agent
of Chagas disease, a chronic infectious illness that affects millions of people worldwide …
of Chagas disease, a chronic infectious illness that affects millions of people worldwide …
Nitric Oxide and Salmonella Pathogenesis
Nitric oxide (NO) and its congeners contribute to the innate immune response to Salmonella.
This enteric pathogen is exposed to reactive nitrogen species (RNS) in the environment and …
This enteric pathogen is exposed to reactive nitrogen species (RNS) in the environment and …
Apoptosis-associated Speck–like protein containing a caspase recruitment domain inflammasomes mediate IL-1β response and host resistance to Trypanosoma cruzi …
The innate immune response to Trypanosoma cruzi infection comprises several pattern
recognition receptors (PRRs), including TLR-2,-4,-7, and-9, as well as the cytosolic receptor …
recognition receptors (PRRs), including TLR-2,-4,-7, and-9, as well as the cytosolic receptor …
Activation of NLRC4 by flagellated bacteria triggers caspase-1–dependent and–independent responses to restrict Legionella pneumophila replication in …
Although NLRC4/IPAF activation by flagellin has been extensively investigated, the
downstream signaling pathways and the mechanisms responsible for infection clearance …
downstream signaling pathways and the mechanisms responsible for infection clearance …
Macrophage inflammatory state in Type 1 diabetes: triggered by NLRP3/iNOS pathway and attenuated by docosahexaenoic acid
Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease characterized by insulin-
producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like …
producing pancreatic β-cell destruction and hyperglycemia. While monocytes and NOD-like …
Lysosomal cathepsins act in concert with Gasdermin-D during NAIP/NLRC4-dependent IL-1β secretion
LM Branco, MP Amaral, H Boekhoff, ABF de Lima… - Cell Death & …, 2022 - nature.com
The NAIP/NLRC4 inflammasome is classically associated with the detection of bacterial
invasion to the cytosol. However, recent studies have demonstrated that NAIP/NLRC4 is …
invasion to the cytosol. However, recent studies have demonstrated that NAIP/NLRC4 is …