Getting sharper: the brain under the spotlight of super-resolution microscopy
Brain cells such as neurons and astrocytes exhibit an extremely elaborate morphology, and
their functional specializations like synapses and glial processes often fall below the …
their functional specializations like synapses and glial processes often fall below the …
Therapeutic potential of opioid receptor heteromers in chronic pain and associated comorbidities
M Gaborit, D Massotte - British Journal of Pharmacology, 2023 - Wiley Online Library
Chronic pain affects 20% to 45% of the global population and is often associated with the
development of anxio‐depressive disorders. Treatment of this debilitating condition remains …
development of anxio‐depressive disorders. Treatment of this debilitating condition remains …
Tau forms synaptic nano-biomolecular condensates controlling the dynamic clustering of recycling synaptic vesicles
Neuronal communication relies on the release of neurotransmitters from various populations
of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities …
of synaptic vesicles. Despite displaying vastly different release probabilities and mobilities …
Super-resolved trajectory-derived nanoclustering analysis using spatiotemporal indexing
Single-molecule localization microscopy techniques are emerging as vital tools to unravel
the nanoscale world of living cells by understanding the spatiotemporal organization of …
the nanoscale world of living cells by understanding the spatiotemporal organization of …
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment
C Danis, E Dupré, O Zejneli, R Caillierez, A Arrial… - Molecular Therapy, 2022 - cell.com
Tau proteins aggregate into filaments in brain cells in Alzheimer's disease and related
disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only …
disorders referred to as tauopathies. Here, we used fragments of camelid heavy-chain-only …
Deep learning-assisted single-atom detection of copper ions by combining click chemistry and fast scan voltammetry
T Hao, H Zhou, P Gai, Z Wang, Y Guo, H Lin… - Nature …, 2024 - nature.com
Cell ion channels, cell proliferation and metastasis, and many other life activities are
inseparable from the regulation of trace or even single copper ion (Cu+ and/or Cu2+). In this …
inseparable from the regulation of trace or even single copper ion (Cu+ and/or Cu2+). In this …
Cavin4 interacts with Bin1 to promote T-tubule formation and stability in develo** skeletal muscle
HP Lo, YW Lim, Z ** at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and …
Accumulation of aggregates of the microtubule‐binding protein Tau is a pathological
hallmark of Alzheimer's disease. While Tau is thought to primarily associate with …
hallmark of Alzheimer's disease. While Tau is thought to primarily associate with …