There is already a societal awareness of the growing impact of nanoscience and
nanotechnology, with nanomaterials (with at least one dimension less than 100 nm) now …

Breast cancer is a leading cause of death for women, with mortality resulting from
metastasis. Metastases are often detected once tumour cells affect the function of solid …

Traditional imaging cytometry uses fluorescence markers to identify specific structures but is
limited in throughput by the labeling process. We develop a label-free technique that …

The onset of distant organ metastasis from primary breast cancer marks the transition to a
stage IV diagnosis. Standard imaging modalities often detect distant metastasis when the …

Before they become invasive, early cancer cells exhibit specific and characteristic changes
that are routinely used by a histopathologist for diagnosis. Currently, these early …

Optical interactions with biological tissue provide powerful tools for study, diagnosis, and
treatment of disease. When optical methods are used in applications involving tissue …

We acquired depth-resolved light scattering measurements from the retinas of triple
transgenic Alzheimer's Disease (3xTg-AD) mice and wild type (WT) age-matched controls …

Field carcinogenesis is the initial stage of cancer progression. Understanding field
carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used …

Measuring capillary oxygenation and the surrounding ultrastructure can allow one to monitor
a microvascular niche and better understand crucial biological mechanisms. However …

Depth resolved label-free detection of structural changes with nanoscale sensitivity is an
outstanding problem in the biological and physical sciences and has significant applications …