Machine learning and decision support in critical care
Clinical data management systems typically provide caregiver teams with useful information,
derived from large, sometimes highly heterogeneous, data sources that are often changing …
derived from large, sometimes highly heterogeneous, data sources that are often changing …
[PDF][PDF] European recommendations for the clinical use of HIV drug resistance testing: 2011 update
Abstract The European HIV Drug Resistance Guidelines Panel, established to make
recommendations to clinicians and virologists, felt that sufficient new information has …
recommendations to clinicians and virologists, felt that sufficient new information has …
FUBAR: a fast, unconstrained bayesian approximation for inferring selection
Abstract Model-based analyses of natural selection often categorize sites into a relatively
small number of site classes. Forcing each site to belong to one of these classes places …
small number of site classes. Forcing each site to belong to one of these classes places …
Artificial intelligence in drug combination therapy
IF Tsigelny - Briefings in bioinformatics, 2019 - academic.oup.com
Currently, the development of medicines for complex diseases requires the development of
combination drug therapies. It is necessary because in many cases, one drug cannot target …
combination drug therapies. It is necessary because in many cases, one drug cannot target …
[HTML][HTML] A pilot study investigating changes in neural processing after mindfulness training in elite athletes
The ability to pay close attention to the present moment can be a crucial factor for performing
well in a competitive situation. Training mindfulness is one approach to potentially improve …
well in a competitive situation. Training mindfulness is one approach to potentially improve …
[HTML][HTML] Combining kernel and model based learning for HIV therapy selection
We present a mixture-of-experts approach for HIV therapy selection. The heterogeneity in
patient data makes it difficult for one particular model to succeed at providing suitable …
patient data makes it difficult for one particular model to succeed at providing suitable …
Predictors of first-line antiretroviral therapy discontinuation due to drug-related adverse events in HIV-infected patients: a retrospective cohort study
Background Drug-related toxicity has been one of the main causes of antiretroviral treatment
discontinuation. However, its determinants are not fully understood. Aim of this study was to …
discontinuation. However, its determinants are not fully understood. Aim of this study was to …
Clinical management of HIV drug resistance
KJ Cortez, F Maldarelli - Viruses, 2011 - pmc.ncbi.nlm.nih.gov
Combination antiretroviral therapy for HIV-1 infection has resulted in profound reductions in
viremia and is associated with marked improvements in morbidity and mortality. Therapy is …
viremia and is associated with marked improvements in morbidity and mortality. Therapy is …
Artificial intelligence in drug treatment
EL Romm, IF Tsigelny - Annual review of pharmacology and …, 2020 - annualreviews.org
The most common applications of artificial intelligence (AI) in drug treatment have to do with
matching patients to their optimal drug or combination of drugs, predicting drug-target or …
matching patients to their optimal drug or combination of drugs, predicting drug-target or …
Multioutput perturbation-theory machine learning (PTML) model of ChEMBL data for antiretroviral compounds
E Vásquez-Domínguez… - Molecular …, 2019 - ACS Publications
Retroviral infections, such as HIV, are, until now, diseases with no cure. Medicine and
pharmaceutical chemistry need and consider it a huge goal to define target proteins of new …
pharmaceutical chemistry need and consider it a huge goal to define target proteins of new …