Machine learning and decision support in critical care

AEW Johnson, MM Ghassemi, S Nemati… - Proceedings of the …, 2016 - ieeexplore.ieee.org
Clinical data management systems typically provide caregiver teams with useful information,
derived from large, sometimes highly heterogeneous, data sources that are often changing …

[PDF][PDF] European recommendations for the clinical use of HIV drug resistance testing: 2011 update

AM Vandamme, RJ Camacho, F Ceccherini-Silberstein… - Aids Rev, 2011 - academia.edu
Abstract The European HIV Drug Resistance Guidelines Panel, established to make
recommendations to clinicians and virologists, felt that sufficient new information has …

FUBAR: a fast, unconstrained bayesian approximation for inferring selection

B Murrell, S Moola, A Mabona, T Weighill… - Molecular biology …, 2013 - academic.oup.com
Abstract Model-based analyses of natural selection often categorize sites into a relatively
small number of site classes. Forcing each site to belong to one of these classes places …

Artificial intelligence in drug combination therapy

IF Tsigelny - Briefings in bioinformatics, 2019 - academic.oup.com
Currently, the development of medicines for complex diseases requires the development of
combination drug therapies. It is necessary because in many cases, one drug cannot target …

[HTML][HTML] A pilot study investigating changes in neural processing after mindfulness training in elite athletes

L Haase, AC May, M Falahpour, S Isakovic… - Frontiers in behavioral …, 2015 - frontiersin.org
The ability to pay close attention to the present moment can be a crucial factor for performing
well in a competitive situation. Training mindfulness is one approach to potentially improve …

[HTML][HTML] Combining kernel and model based learning for HIV therapy selection

S Parbhoo, J Bogojeska, M Zazzi, V Roth… - AMIA Summits on …, 2017 - ncbi.nlm.nih.gov
We present a mixture-of-experts approach for HIV therapy selection. The heterogeneity in
patient data makes it difficult for one particular model to succeed at providing suitable …

Predictors of first-line antiretroviral therapy discontinuation due to drug-related adverse events in HIV-infected patients: a retrospective cohort study

MCF Prosperi, M Fabbiani, I Fanti, M Zaccarelli… - BMC infectious …, 2012 - Springer
Background Drug-related toxicity has been one of the main causes of antiretroviral treatment
discontinuation. However, its determinants are not fully understood. Aim of this study was to …

Clinical management of HIV drug resistance

KJ Cortez, F Maldarelli - Viruses, 2011 - pmc.ncbi.nlm.nih.gov
Combination antiretroviral therapy for HIV-1 infection has resulted in profound reductions in
viremia and is associated with marked improvements in morbidity and mortality. Therapy is …

Artificial intelligence in drug treatment

EL Romm, IF Tsigelny - Annual review of pharmacology and …, 2020 - annualreviews.org
The most common applications of artificial intelligence (AI) in drug treatment have to do with
matching patients to their optimal drug or combination of drugs, predicting drug-target or …

Multioutput perturbation-theory machine learning (PTML) model of ChEMBL data for antiretroviral compounds

E Vásquez-Domínguez… - Molecular …, 2019 - ACS Publications
Retroviral infections, such as HIV, are, until now, diseases with no cure. Medicine and
pharmaceutical chemistry need and consider it a huge goal to define target proteins of new …