Antibiotic resistance in Enterobacteriaceae: mechanisms and clinical implications
J Iredell, J Brown, K Tagg - Bmj, 2016 - bmj.com
Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …
increasingly dominated by the mobilization of continuously expressed single genes that …
Anti-virulence strategies to target bacterial infections
S Mühlen, P Dersch - How to Overcome the Antibiotic Crisis: Facts …, 2016 - Springer
Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …
Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity
Host recognition of pathogen-associated molecular patterns (PAMPs) initiates an innate
immune response that is critical for pathogen elimination and engagement of adaptive …
immune response that is critical for pathogen elimination and engagement of adaptive …
Novel Chalcone–Thiazole Hybrids as Potent Inhibitors of Drug Resistant Staphylococcus aureus
A series of novel hybrids possessing chalcone and thiazole moieties were synthesized and
evaluated for their antibacterial activities. In general this class of hybrids exhibited potency …
evaluated for their antibacterial activities. In general this class of hybrids exhibited potency …
The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase
A series of novel 2-Amino-4-Methylthiazole analogs were developed via three-step reaction
encompassing hydrazine-1-carboximidamide motif to combat Gram-positive and Gram …
encompassing hydrazine-1-carboximidamide motif to combat Gram-positive and Gram …
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica
H Salvail, EA Groisman - PLoS genetics, 2020 - journals.plos.org
To survive an environmental stress, organisms must detect the stress and mount an
appropriate response. One way that bacteria do so is by phosphorelay systems that respond …
appropriate response. One way that bacteria do so is by phosphorelay systems that respond …
Exploring fluorinated heptose phosphate analogues as inhibitors of HldA and HldE, key enzymes in the biosynthesis of lipopolysaccharide
J Cao, JI Veytia-Bucheli, L Liang, J Wouters… - Bioorganic …, 2024 - Elsevier
The growing threat of bacterial resistance to antibiotics has led to the rise of anti-virulence
strategies as a promising approach. These strategies aim to disarm bacterial pathogens and …
strategies as a promising approach. These strategies aim to disarm bacterial pathogens and …
Activation of Purine Biosynthesis Suppresses the Sensitivity of E. coli gmhA Mutant to Antibiotics
TA Seregina, IY Petrushanko, PI Zaripov… - International Journal of …, 2023 - mdpi.com
Inactivation of enzymes responsible for biosynthesis of the cell wall component of ADP-
glycero-manno-heptose causes the development of oxidative stress and sensitivity of …
glycero-manno-heptose causes the development of oxidative stress and sensitivity of …
Potentiating Activity of GmhA Inhibitors on Gram-Negative Bacteria
Inhibition of the biosynthesis of bacterial heptoses opens novel perspectives for
antimicrobial therapies. The enzyme GmhA responsible for the first committed biosynthetic …
antimicrobial therapies. The enzyme GmhA responsible for the first committed biosynthetic …
Photoredox catalytic aminomethylation of sulfonylthiazoles
L Meng, J Dong, Y Tang, H Yang, L Sun, J Chen… - Green …, 2024 - pubs.rsc.org
A photoredox catalytic aliphatic C (sp3)–H thiazolation of tertiary amines was developed,
affording the biologically valuable alkylated thiazoles via the aminomethylation of …
affording the biologically valuable alkylated thiazoles via the aminomethylation of …