Proteins guide the flows of information, energy, and matter that make life possible by
accelerating transport and chemical reactions, by allosterically modulating these reactions …

A major goal in biomedical science is to move beyond static images of proteins and other
biological macromolecules to the internal dynamics underlying their function. This level of …

Photolyase is an enzyme that uses light to catalyze DNA repair. To capture the reaction
intermediates involved in the enzyme's catalytic cycle, we conducted a time-resolved …

The binding and release of ligands from their protein targets is central to fundamental
biological processes as well as to drug discovery. Photopharmacology introduces chemical …

After decades of diligent development at synchrotron light sources, the field of time-resolved
crystallography (TRX) is elevating to new heights. Driven by the appearance of X-ray free …

Time-Resolved Serial Femtosecond Crystallography (TR-SFX) conducted at X-ray Free
Electron Lasers (XFELs) has become a powerful tool for capturing macromolecular structural …

Serial crystallography (SX) involves combining observations from a very large number of
diffraction patterns coming from crystals in random orientations. To compile a complete data …

Time-resolved diagnostics at free-electron laser (FEL) facilities, in particular electron beam
longitudinal phase space (LPS) and FEL power profile measurements, provide information …

Serial crystallography is a rapidly growing method that can yield structural insights from
microcrystals that were previously considered to be too small to be useful in conventional X …

DJ-1 (PARK7) is an intensively studied protein whose cytoprotective activities are
dysregulated in multiple diseases. DJ-1 has been reported as having two distinct enzymatic …