Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Metastases account for the great majority of cancer-associated deaths, yet this complex
process remains the least understood aspect of cancer biology. As the body of research …

Cancers develop in complex tissue environments, which they depend on for sustained
growth, invasion and metastasis. Unlike tumor cells, stromal cell types within the tumor …

The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

It is well established that organs of future metastasis are not passive receivers of circulating
tumour cells, but are instead selectively and actively modified by the primary tumour before …

Metastasis is the main cause of death in people with cancer. To colonize distant organs,
circulating tumour cells must overcome many obstacles through mechanisms that we are …

Lung cancer is a major global health problem, as it is the leading cause of cancer-related
deaths worldwide. Major advances in the identification of key mutational alterations have led …

Lung metastasis is the major cause of breast cancer-related mortality. The neutrophil-
associated inflammatory microenvironment aids tumor cells in metastatic colonization in …

Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

The development of life-threatening cancer metastases at distant organs requires
disseminated tumour cells' adaptation to, and co-evolution with, the drastically different …