Niches are local tissue microenvironments that maintain and regulate stem cells.
Haematopoiesis provides a model for understanding mammalian stem cells and their …

Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

The canonical WNT/β-catenin signaling pathway governs a myriad of biological processes
underlying the development and maintenance of adult tissue homeostasis, including …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …

Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …

Wnt signaling is involved in self-renewal and maintenance of hematopoietic stem cells
(HSCs); however, the particular role of noncanonical Wnt signaling in regulating HSCs in …

A strict balance between self-renewal and differentiation of hematopoietic stem cells (HSCs)
is required in order to maintain homeostasis, as well as to efficiently respond to injury and …

Hematopoietic stem cells (HSCs) represent one of the first recognized somatic stem cell
types. As such, nearly 200 genes have been examined for roles in HSC function in knockout …

Objectives: To summarize the effects of the bone marrow niche on hematopoiesis and
leukemogenesis and discuss the chemotherapy resistance that can arise from interactions …

ARTICLE SERIES: Stem Cells Cell Science at a Glance 3529 dormancy (Trumpp et al.,
2010) and, thereby, maintain homeostasis both in the steady state as well as in response to …