The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Melatonin, N‐acetyl‐5‐methoxytryptamine, an evolutionally old molecule, is produced by the
pineal gland in vertebrates, and it binds with high affinity to melatonin receptors, which are …

Abstract Melatonin (5‐methoxy‐N‐acetyltryptamine) binds with high affinity and specificity to
membrane receptors. Several receptor subtypes exist in different species, of which the …

In vitro follicle growth and oocyte maturation still has a series of limitations, since not all
oocytes matured in vitro have the potential to develop in viable embryos. One of the factors …

Melatonin, an endogenously synthesized indolamine, is a powerful antioxidant exerting
beneficial action in many pathological conditions. Melatonin protects from oxidative stress in …

Numerous physiological functions of the pineal gland hormone melatonin are mediated via
activation of two G-protein-coupled receptors, MT1 and MT2. The melatonergic drugs on the …

Indole heterocycles hold an important position in chemical landscape because of their
prominence in natural products and pharmaceuticals. Consequently, development of new …

Melatonin, a hormone secreted by the pineal gland, works directly and indirectly as a free
radical scavenger. Its other physiological or pharmacological activities could be dependent …

The long‐anticipated high‐resolution structures of the human melatonin G protein‐coupled
receptors MT1 and MT2, involved in establishing and maintaining circadian rhythm, were …

Abstract Huntington's disease (HD), a devastating neurodegenerative disorder, is
characterized by progressive motor dysfunction, emotional disturbances, dementia, weight …