Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide, and fatty acid
metabolism has been well studied. Short-chain fatty acids (SCFAs) have been less …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Utilization of lipids as energy substrates after birth causes cardiomyocyte (CM) cell-cycle
arrest and loss of regenerative capacity in mammalian hearts. Beyond energy provision …

Intramyocardial injection of hydrogels possesses great potential in the minimally invasive
treatment of myocardial infarction (MI), but the current injectable hydrogels lack conductivity …

Background: Inhibiting SDH (succinate dehydrogenase), with the competitive inhibitor
malonate, has shown promise in ameliorating ischemia/reperfusion injury. However, key for …

Aims Metabolic switching during heart development contributes to postnatal cardiomyocyte
(CM) cell cycle exit and loss of regenerative capacity in the mammalian heart. Metabolic …

Aging is associated with a decline in mitochondrial function which may contribute to age-
related diseases such as neurodegeneration, cancer, and cardiovascular diseases …

The heart undergoes a dynamic maturation process following birth, in response to a wide
range of stimuli, including both physiological and pathological cues. This process entails …

Background: The regenerative capacity of the heart after myocardial infarction is limited. Our
previous study showed that ectopic introduction of 4 cell cycle factors (4F; CDK1 [cyclin …