Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …

Pluripotent stem cell (PSC)-derived human brain organoids enable the study of human brain
development in vitro. Typically, the fate of PSCs is guided into subsequent specification …

Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …

The neocortex exhibits a six-layered structure that is formed by radial migration of excitatory
neurons, for which the multipolar-to-bipolar transition of immature migrating multipolar …

In develo** brains, activity-dependent remodeling facilitates the formation of precise
neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; …

The evolutionary expansion of the mammalian brain, notably the neocortex, provides a
platform for the higher cognitive abilities that characterize humans. Cortical expansion is …

The concomitant occurrence of tissue growth and organization is a hallmark of organismal
development,–. This often means that proliferating and differentiating cells are found at the …

Glutamatergic neurons of the mammalian cerebral cortex originate from radial glia (RG)
progenitors in the ventricular zone (VZ). During corticogenesis, neuroblasts migrate toward …

Dynein recruitment to the nuclear envelope is required for pre-mitotic nucleus-centrosome
interactions in nonneuronal cells and for apical nuclear migration in neural stem cells. In …