Gut microbiota controlling radiation-induced enteritis and intestinal regeneration

I Moraitis, J Guiu, J Rubert - Trends in Endocrinology & Metabolism, 2023 - cell.com
Cancer remains the second leading cause of mortality, with nearly 10 million deaths
worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However …

Regeneration, rejuvenation, and replacement: turning back the clock on tissue aging

TA Rando, DL Jones - Cold Spring Harbor perspectives …, 2021 - cshperspectives.cshlp.org
While some animals, such as planaria and hydra, appear to be capable of seemingly
endless cycles of regeneration, most animals experience a gradual decline in fitness and …

Short-term post-fast refeeding enhances intestinal stemness via polyamines

S Imada, S Khawaled, H Shin, SW Meckelmann… - Nature, 2024 - nature.com
For over a century, fasting regimens have improved health, lifespan and tissue regeneration
in diverse organisms, including humans,,,,–. However, how fasting and post-fast refeeding …

Inulin diet uncovers complex diet-microbiota-immune cell interactions remodeling the gut epithelium

RO Corrêa, PR Castro, JL Fachi, VD Nirello… - Microbiome, 2023 - Springer
Background The continuous proliferation of intestinal stem cells followed by their tightly
regulated differentiation to epithelial cells is essential for the maintenance of the gut …

Synergistic strategies for gastrointestinal cancer care: unveiling the benefits of immunonutrition and microbiota modulation

S Martinelli, I Lamminpää, EN Dübüş, D Sarıkaya… - Nutrients, 2023 - mdpi.com
Gastrointestinal (GI) cancers are a group of highly prevalent malignant tumors affecting the
gastrointestinal tract. Globally, one in four cancer cases and one in three cancer deaths are …

Subversion of niche-signalling pathways in colorectal cancer: what makes and breaks the intestinal stem cell

N Sphyris, MC Hodder, OJ Sansom - Cancers, 2021 - mdpi.com
Simple Summary The intestinal epithelium—a single-cell layer lining the luminal surface of
the small and large intestine—comprises an array of highly specialized cell types that …

Intermittent fasting-induced biomolecular modifications in rat tissues detected by ATR-FTIR spectroscopy and machine learning algorithms

T Ceylani, HT Teker, G Samgane, R Gurbanov - Analytical Biochemistry, 2022 - Elsevier
This study aimed to reveal the intermittent fasting-induced alterations in biomolecules of the
liver, ileum, and colon tissues of rats using Support Vector Machine (SVM) and Linear …

An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal epithelial cells

MJ Cotton, P Ariel, K Chen, VA Walcott, M Dixit… - Scientific Reports, 2024 - nature.com
The intestinal epithelium dynamically controls cell cycle, yet no experimental platform exists
for directly analyzing cell cycle phases in non-immortalized human intestinal epithelial cells …

A Screening of Native (Poly) phenols and Gut‐Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan‐3‐ol Metabolite

J Rubert, P Gatto, M Pancher… - Molecular Nutrition & …, 2022 - Wiley Online Library
Scope Epidemiological evidence suggests that a reduced risk of colorectal cancer (CRC) is
correlated with high consumption of fruits and vegetables, which are major sources of fiber …

Three specific gut bacteria in the occurrence and development of colorectal cancer: a concerted effort

D Gong, AG Adomako-Bonsu, M Wang, J Li - PeerJ, 2023 - peerj.com
Colorectal cancer (CRC), which develops from the gradual evolution of tubular adenomas
and serrated polyps in the colon and rectum, has a poor prognosis and a high mortality rate …