The process of protein misfolding and aggregation has been associated with an increasing
number of pathological conditions that include Alzheimer's and Parkinson's diseases, and …

Therapeutic proteins such as antibodies constitute the most rapidly growing class of
pharmaceuticals for use in diverse clinical settings including cancer, chronic inflammatory …

Amyloid fibrils are insoluble mainly β-sheet aggregates of proteins or peptides. The multi-
step process of amyloid aggregation is one of the major research topics in structural biology …

Understanding the early steps of aggregation at atomic detail might be crucial for the rational
design of therapeutics preventing diseases associated with amyloid deposits. In this paper …

Therapeutic proteins such as antibodies are playing an increasingly prominent role in the
treatment of numerous diseases including cancer and rheumatoid arthritis. However, these …

The replica exchange molecular dynamics (REMD) approach is applied to four oligomeric
peptide systems. At physiologically relevant temperature values REMD samples …

The irreversible spread of new resistance mechanisms against existing therapeutical
antibiotics has led to the development of technologies and strategies for the glycosylation …

Reduced computer modeling of proteins now has a history of about 30 years. In spite of the
enormous increase in computing abilities, reduced models are still very important tools for …

A major focus in the current development in nanotechnology and biotechnology is to find
suitable molecular materials that are amenable to engineering design. Self-assembling …

Therapeutic antibodies of many different IgG subclasses (IgG1, IgG2 and IgG4) are used in
the treatment of various cancers, rheumatoid arthritis and other inflammatory and infectious …