Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial
enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types …

Eukaryotic gene regulation is a combinatorial, dynamic, and quantitative process that plays
a vital role in development and disease and can be modeled at a systems level in gene …

Cells integrate mechanical cues to direct fate specification to maintain tissue function and
homeostasis. While disruption of these cues is known to lead to aberrant cell behavior and …

The genome folds into complex configurations and structures thought to profoundly impact
its function. The intricacies of this dynamic structure-function relationship are not well …

Genome‐wide transcriptional activity involves the binding of many transcription factors (TFs)
to thousands of sites in the genome. Pioneer TFs are a class of TFs that maintain open …

Compact chromatin is closely linked with gene silencing in part by sterically masking access
to promoters, inhibiting transcription factor binding and preventing polymerase from …

Single-cell CRISPR screens link genetic perturbations to transcriptional states, but high-
throughput methods connecting these induced changes to their regulatory foundations are …

Cis-regulatory elements (CREs) are pivotal in orchestrating gene expression throughout
diverse biological systems. Accurate identification and in-depth characterization of functional …

Mammalian pluripotent cells first segregate into neuroectoderm (NE), or mesoderm and
endoderm (ME), characterized by lineage-specific transcriptional programs and chromatin …