Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Until the identification of leptin, the first adipokine discovered in 1994, adipose tissue was
considered only as an energy storage tissue. However, it is now clear that adipose tissue is …

Visceral adipose tissue plays a critical role in numerous diseases. Although imaging studies
often show adipose involvement in abdominal diseases, their outcomes may vary from being …

Background: Obesity is a growing health problem and associated with immune dysfunction.
Sepsis is defined as systemic inflammatory response syndrome that occurs during infection …

Sepsis has always been considered as a big challenge for pharmaceutical companies in
terms of discovering and designing new therapeutics. The pathogenesis of sepsis involves …

Purpose Sepsis has become a global health problem with rising incidence and high
mortality, creating a substantial social and economic burden. Early diagnosis and treatment …

Objective: Observational studies report lower mortality in obese than in lean critically ill
patients, an association referred to as the “obesity paradox.” This may suggest a possible …

The recent pandemic Sars-CoV2 infection and studies on previous influenza epidemic have
drawn attention to the association between the obesity and infectious diseases susceptibility …

The adipokine leptin realizes signal transduction via four different leptin receptor (OB-R)
isoforms. The amount of functionally active OB-R, however, is affected by constitutive …

Background Muscle weakness is a frequently occurring complication of sepsis, associated
with increased morbidity and mortality. Interestingly, obesity attenuates sepsis‐induced …