The concept of genetic balance traces back to the early days of genetics. Additions or
subtractions of single chromosomes to the karyotype (aneuploidy) produced greater impacts …

Several contributing factors have been implicated in evolutionary rate heterogeneity among
proteins, but their evolutionary mechanisms remain poorly characterized. The recently …

Rubisco is the primary entry point for carbon into the biosphere. However, rubisco is widely
regarded as inefficient leading many to question whether the enzyme can adapt to become …

A genome-scale genetic interaction map was constructed by examining 5.4 million gene-
gene pairs for synthetic genetic interactions, generating quantitative genetic interaction …

Identification of protein–protein interactions often provides insight into protein function, and
many cellular processes are performed by stable protein complexes. We used tandem …

Proteins often function as components of multi-subunit complexes. Despite its long history as
a model organism, no large-scale analysis of protein complexes in Escherichia coli has yet …

We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461
proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were …

Conditional temperature-sensitive (ts) mutations are valuable reagents for studying essential
genes in the yeast Saccharomyces cerevisiae. We constructed 787 ts strains, covering 497 …

Background Most proteins interact with only a few other proteins while a small number of
proteins (hubs) have many interaction partners. Hub proteins and non-hub proteins differ in …

Recent analyses of high-throughput protein interaction data coupled with large-scale
investigations of evolutionary properties of interaction networks have left some unanswered …