Immune modulation by human secreted RNases at the extracellular space
The ribonuclease A superfamily is a vertebrate-specific family of proteins that encompasses
eight functional members in humans. The proteins are secreted by diverse innate immune …
eight functional members in humans. The proteins are secreted by diverse innate immune …
Oxidative stress: a new target for pancreatic cancer prognosis and treatment
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of tumors, and its
incidence is rising worldwide. Survival can be improved when tumors are detected at an …
incidence is rising worldwide. Survival can be improved when tumors are detected at an …
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling
F Wang, L Wang, C Qu, L Chen, Y Geng, C Cheng… - BMC cancer, 2021 - Springer
Background Kaempferol, a natural flavonoid, exhibits anticancer properties by scavenging
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …
reactive oxygen species (ROS). However, increasing evidence has demonstrated that …
Cell‐free protein synthesis of a cytotoxic cancer therapeutic: Onconase production and a just‐add‐water cell‐free system
Biotherapeutics have many promising applications, such as anti‐cancer treatments, immune
suppression, and vaccines. However, due to their biological nature, some biotherapeutics …
suppression, and vaccines. However, due to their biological nature, some biotherapeutics …
[HTML][HTML] Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition
M Cordani, E Oppici, I Dando, E Butturini… - Molecular …, 2016 - Elsevier
Mutations in TP53 gene play a pivotal role in tumorigenesis and cancer development. Here,
we report that gain-of-function mutant p53 proteins inhibit the autophagic pathway favoring …
we report that gain-of-function mutant p53 proteins inhibit the autophagic pathway favoring …
The cell activation phenomena in the cold atmospheric plasma cancer treatment
Abstract Cold Atmospheric Plasma (CAP) is an ionized gas with a near room temperature.
CAP is a controllable source for reactive species, neutral particles, electromagnetic field and …
CAP is a controllable source for reactive species, neutral particles, electromagnetic field and …
Reactive oxygen species and targeted therapy for pancreatic cancer
L Zhang, J Li, L Zong, X Chen, K Chen… - Oxidative medicine …, 2016 - Wiley Online Library
Pancreatic cancer is the fourth leading cause of cancer‐related death in the United States.
Reactive oxygen species (ROS) are generally increased in pancreatic cancer cells …
Reactive oxygen species (ROS) are generally increased in pancreatic cancer cells …
Enzyme-based autophagy in anti-neoplastic management: from molecular mechanisms to clinical therapeutics
Autophagy is an evolutionarily conserved self-cannibalization process commonly found in
all eukaryotic cells. Through autophagy, long-lived or damaged organelles, superfluous …
all eukaryotic cells. Through autophagy, long-lived or damaged organelles, superfluous …
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells
MS Gilardini Montani, M Granato, C Santoni… - Cellular Oncology, 2017 - Springer
Abstract Purpose Histone deacetylase inhibitors (HDACi) are anti-neoplastic agents that are
known to affect the growth of different cancer types, but their underlying mechanisms are still …
known to affect the growth of different cancer types, but their underlying mechanisms are still …
Protein synthesis directly from PCR: progress and applications of cell-free protein synthesis with linear DNA
SM Schinn, A Broadbent, WT Bradley, BC Bundy - New biotechnology, 2016 - Elsevier
Highlights•PCR products can be used to make proteins quickly and easily in a cell-free
system.•Recent advances have widened the application space of such cell-free …
system.•Recent advances have widened the application space of such cell-free …