Survival improves when cancer is detected early. However,~ 50% of cancers are at an
advanced stage when diagnosed. Early detection of cancer or precancerous change allows …

The term monoclonal gammopathy of renal significance (MGRS) was introduced by the
International Kidney and Monoclonal Gammopathy Research Group (IKMG) in 2012. The …

Abstract Disease Overview Multiple myeloma accounts for approximately 10% of
hematologic malignancies. Diagnosis The diagnosis requires≥ 10% clonal bone marrow …

Background Monoclonal gammopathy of undetermined significance (MGUS) occurs in
approximately 3% of persons 50 years of age or older. Methods We studied 1384 patients …

Recent advances in the treatment of multiple myeloma have increased the need for accurate
diagnosis of the disease. The detection of bone and bone marrow lesions is crucial in the …

The world is witnessing a rapid demographic shift towards an older population, a trend with
major medical, social, economic and political implications. Aging is a multifaceted process …

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening, progressive,
infiltrative disease caused by the deposition of transthyretin amyloid fibrils in the heart, and …

Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by
substantial intraclonal genetic heterogeneity. Although therapeutic advances made in the …

Recent genetic analyses of large populations have revealed that somatic mutations in
hematopoietic cells leading to clonal expansion are commonly acquired during human …

Summary This International Myeloma Working Group consensus updates the disease
definition of multiple myeloma to include validated biomarkers in addition to existing …