Biomolecular condensates are two-and three-dimensional compartments in eukaryotic cells
that concentrate specific collections of molecules without an encapsulating membrane …

The fruit fly, Drosophila melanogaster, has been used to understand fundamental principles
of genetics and biology for over a century. Drosophila is now also considered an essential …

Chronic immune activation is a major complication of antiretroviral therapy (ART) for HIV
infection and can cause a devastating immune reconstitution inflammatory syndrome (IRIS) …

Nucleolar function and the cellular response to DNA damage have long been studied as
distinct disciplines. New research and a new appreciation for proteins holding multiple …

Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat)
protein, which has several functions that promote viral replication, pathogenesis, and …

Transcription of ribosomal RNA (rRNA) by RNA Polymerase (Pol) I in the nucleolus is
necessary for ribosome biogenesis, which is intimately tied to cell growth and proliferation …

Viruses are small obligatory parasites and as a consequence, they have developed
sophisticated strategies to exploit the host cell's functions to create an environment that …

Significance: An emerging concept in DNA repair mechanisms is the evidence that some
key enzymes, besides their role in the maintenance of genome stability, display also …

Nucleoli are dynamic nuclear condensates in eukaryotic cells that originate through
ribosome biogenesis at loci that harbor the ribosomal DNA. These loci are known as …

Due to their exceptional simplicity of organization, viruses rely on the resources, molecular
mechanisms, macromolecular complexes, regulatory pathways, and functional …