Alzheimer's disease (AD) and the mechanisms underlying its etiology and progression are
complex and multifactorial. The higher AD risk in women may serve as a clue to better …

X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

In somatic nuclei of female therian mammals, the two X chromosomes display very different
chromatin states: One X is typically euchromatic and transcriptionally active, and the other is …

The human X chromosome has a unique biology that was shaped by its evolution as the sex
chromosome shared by males and females. We have determined 99.3% of the euchromatic …

Identifying functional regions in the human genome is a major goal in human genetics. Great
efforts have been made to functionally annotate the human genome either through …

RNA molecules can attach to chromatin. It remains difficult to know what RNAs are
associated with chromatin and where the genomic target loci of these RNAs are. Here, we …

ABSTRACT X chromosome inactivation (XCI) is a key developmental process taking place
in female mammals to compensate for the imbalance in the dosage of X-chromosomal …

▪ Abstract Dosage compensation in mammals is achieved by the transcriptional inactivation
of one X chromosome in female cells. From the time X chromosome inactivation was initially …

The development of genetic sex determination and cytologically distinct sex chromosomes
leads to the potential problem of gene dosage imbalances between autosomes and sex …

Epigenetics refers to a variety of processes that have heritable effects on gene expression
programs without changes in DNA sequence. Key players in epigenetic control are chemical …