Transition metal-mediated formation of C–N bonds is an essential synthetic methodology.
The discovery of the Chan–Lam amination provided a C–N bond forming process that was …

Chan‐Lam reactions hold promise as one of the most efficient synthetic methods to construct
various carbon‐heteroatom or carbon‐carbon bonds. Recently, a series of Chan‐Lam …

Metal‐catalyzed cross‐coupling reactions belong to the most important transformations in
organic synthesis. Copper catalysis has received great attention owing to the low toxicity …

Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …

Chemical modification of proteins provides powerful tools to realize a broad range of
exciting biological applications, including the development of new classes of …

Bioconjugation chemistry has been used to prepare modified biomolecules with functions
beyond what nature intended. Central to these techniques is the development of highly …

Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

The amidated peptides are an important class of biologically active compounds due to their
unique biological properties and wide applications as potential peptide drugs and …

Bioconjugation technologies have revolutionized the practice of biology and medicine by
allowing access to novel biomolecular scaffolds. New methods for residue-selective …

Ribosomally expressed proteins perform multiple, versatile, and specialized tasks
throughout Nature. In modern times, chemically modified proteins, including improved …