Translational regulation of environmental adaptation in bacteria
Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …
The ongoing quest to crack the genetic code for protein production
Understanding the genetic design principles that determine protein production remains a
major challenge. Although the key principles of gene expression were discovered 50 years …
major challenge. Although the key principles of gene expression were discovered 50 years …
Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing
Shine-Dalgarno (SD) motifs are thought to play an important role in translational initiation in
bacteria. Paradoxically, ribosome profiling studies in E. coli show no correlation between the …
bacteria. Paradoxically, ribosome profiling studies in E. coli show no correlation between the …
Comprehensive quantitative modeling of translation efficiency in a genome‐reduced bacterium
Translation efficiency has been mainly studied by ribosome profiling, which only provides an
incomplete picture of translation kinetics. Here, we integrated the absolute quantifications of …
incomplete picture of translation kinetics. Here, we integrated the absolute quantifications of …
A high-resolution transcriptome map identifies small RNA regulation of metabolism in the gut microbe Bacteroides thetaiotaomicron
Bacteria of the genus Bacteroides are common members of the human intestinal microbiota
and important degraders of polysaccharides in the gut. Among them, the species …
and important degraders of polysaccharides in the gut. Among them, the species …
The diversity of Shine-Dalgarno sequences sheds light on the evolution of translation initiation
ABSTRACT Shine-Dalgarno (SD) sequences, the core element of prokaryotic ribosome-
binding sites, facilitate mRNA translation by base-pair interaction with the anti-SD (aSD) …
binding sites, facilitate mRNA translation by base-pair interaction with the anti-SD (aSD) …
Pervasive translation in Mycobacterium tuberculosis
C Smith, JG Canestrari, AJ Wang, MM Champion… - Elife, 2022 - elifesciences.org
Most bacterial ORFs are identified by automated prediction algorithms. However, these
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …
algorithms often fail to identify ORFs lacking canonical features such as a length of> 50 …
Structural basis of sequestration of the anti-Shine-Dalgarno sequence in the Bacteroidetes ribosome
Genomic studies have indicated that certain bacterial lineages such as the Bacteroidetes
lack Shine-Dalgarno (SD) sequences, and yet with few exceptions ribosomes of these …
lack Shine-Dalgarno (SD) sequences, and yet with few exceptions ribosomes of these …
Ribosomes lacking bS21 gain function to regulate protein synthesis in Flavobacterium johnsoniae
Abstract Ribosomes of Bacteroidia (formerly Bacteroidetes) fail to recognize Shine-Dalgarno
(SD) sequences even though they harbor the anti-SD (ASD) of 16S rRNA. Inhibition of SD …
(SD) sequences even though they harbor the anti-SD (ASD) of 16S rRNA. Inhibition of SD …
The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron
Paramount to human health, symbiotic bacteria in the gastrointestinal tract rely on the
breakdown of complex polysaccharides to thrive in this sugar-deprived environment. Gut …
breakdown of complex polysaccharides to thrive in this sugar-deprived environment. Gut …