[HTML][HTML] Lipopolysaccharide-induced model of neuroinflammation: mechanisms of action, research application and future directions for its use

A Skrzypczak-Wiercioch, K Sałat - Molecules, 2022 - mdpi.com
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its
consequences still remain a significant problem in medicine. Acute inflammatory responses …

The role of Toll-like receptors and neuroinflammation in Parkinson's disease

A Heidari, N Yazdanpanah, N Rezaei - Journal of Neuroinflammation, 2022 - Springer
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

The lung microbiome regulates brain autoimmunity

L Hosang, RC Canals, FJ van der Flier, J Hollensteiner… - Nature, 2022 - nature.com
Lung infections and smoking are risk factors for multiple sclerosis, a T-cell-mediated
autoimmune disease of the central nervous system. In addition, the lung serves as a niche …

[HTML][HTML] Interplay of gut microbiota and oxidative stress: Perspective on neurodegeneration and neuroprotection

S Shandilya, S Kumar, NK Jha, KK Kesari… - Journal of Advanced …, 2022 - Elsevier
Background Recent research on the implications of gut microbiota on brain functions has
helped to gather important information on the relationship between them. Pathogenesis of …

A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites

H Shi, X Ge, X Ma, M Zheng, X Cui, W Pan, P Zheng… - Microbiome, 2021 - Springer
Background Cognitive impairment, an increasing mental health issue, is a core feature of the
aging brain and neurodegenerative diseases. Industrialized nations especially, have …

Gut microbial molecules in behavioural and neurodegenerative conditions

BD Needham, R Kaddurah-Daouk… - Nature Reviews …, 2020 - nature.com
Mounting evidence suggests that the gut microbiome impacts brain development and
function. Gut–brain connections may be mediated by an assortment of microbial molecules …

The endotoxin hypothesis of neurodegeneration

GC Brown - Journal of neuroinflammation, 2019 - Springer
The endotoxin hypothesis of neurodegeneration is the hypothesis that endotoxin causes or
contributes to neurodegeneration. Endotoxin is a lipopolysaccharide (LPS), constituting …

Short-chain fatty acids and lipopolysaccharide as mediators between gut dysbiosis and amyloid pathology in Alzheimer's disease

M Marizzoni, A Cattaneo, P Mirabelli… - Journal of …, 2020 - journals.sagepub.com
Background: Metagenomic data support an association between certain bacterial strains
and Alzheimer's disease (AD), but their functional dynamics remain elusive. Objective: To …

Gut–brain axis: role of gut microbiota on neurological disorders and how probiotics/prebiotics beneficially modulate microbial and immune pathways to improve brain …

K Suganya, BS Koo - International journal of molecular sciences, 2020 - mdpi.com
The gut microbiome acts as an integral part of the gastrointestinal tract (GIT) that has the
largest and vulnerable surface with desirable features to observe foods, nutrients, and …

The endotoxin hypothesis of Parkinson's disease

GC Brown, M Camacho… - Movement …, 2023 - Wiley Online Library
The endotoxin hypothesis of Parkinson's disease (PD) is the idea that lipopolysaccharide
(LPS) endotoxins contribute to the pathogenesis of this disorder. LPS endotoxins are found …