Leprosy is best understood as two conjoined diseases. The first is a chronic mycobacterial
infection that elicits an extraordinary range of cellular immune responses in humans. The …

The early secreted antigenic target 6 kDa protein (ESAT-6) is a potent T-cell protein antigen
synthesized by Mycobacterium tuberculosis. Its corresponding gene (esat-6) is located in …

Abstract Background The genome of Mycobacterium tuberculosis H37Rv has five copies of
a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 …

In this paper we describe identification and characterization of Mycobacterium leprae ESAT-
6 (L-ESAT-6), the homologue of M. tuberculosis ESAT-6 (T-ESAT-6). T-ESAT-6 is expressed …

Mycobacterium leprae, the causative agent of leprosy, is an obligate intracellular pathogen.
M. leprae can infect a variety of cells in vivo, including epithelial cells, muscle cells, and …

In an attempt to unify the genetic and biological research on Mycobacterium leprae, the
aetiological agent of leprosy, a cosmid library was constructed and then ordered by a …

A putative serine protease expressed in vivo by Mycobacterium avium subsp.
paratuberculosis was isolated from a lambda gt11 genomic expression library by screening …

In contrast to other bacterial species, mycobacteria were thus far considered to contain
groEL and groES genes that are present on separate loci on their chromosomes, Here, by …

Pooled polyvalent sera from lepromatous leprosy patients were used to screen a lambda
gt11 recombinant DNA expression library of Mycobacterium leprae in order to identify the …

By screening a Mycobacterium lepraeλgt11 genomic DNA library with leprosy‐patient sera
we have previously identified 50 recombinant clones that expressed novel M. leprae …