Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …

Substantial evidence indicates that the lateral septum (LS) plays a critical role in regulating
processes related to mood and motivation. This review presents findings from the basic …

PROTEIN-TYROSINE kinases (PTKs) and protein-tyrosine phosphatases (PTPs) are key
enzymes in signal-transduction pathways for a wide range of cellular processes1, 2. PTKs …

NMDA receptors (NMDARs) play an important role in neural plasticity including long-term
potentiation and long-term depression, which are likely to explain their importance for …

The past decade has brought tremendous progress in unraveling the pathophysiology of
Alzheimer's disease (AD). While increasingly sophisticated immunotherapy targeting soluble …

As the population ages, neurodegenerative diseases such as Alzheimer's disease (AD) are
becoming a significant burden on patients, their families, and health-care systems …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, afflicting more than
one-third of people over the age of 85. While many therapies for AD are in late-stage clinical …

NMDA receptor (NMDAR)-mediated excitotoxicity plays an important role in several CNS
disorders, including epilepsy, stroke, and ischemia. Here we demonstrate the involvement of …