The orphan nuclear receptor steroidogenic factor 1 (SF-1, also called Ad4BP, encoded by
the NR5A1 gene) is an essential regulator of endocrine development and function. Initially …

Androgen deficiency (hypogonadism) affects males of all ages. Testosterone replacement
therapy (TRT) is effective in restoring serum testosterone and relieving symptoms. TRT …

Background Atrazine is a potent endocrine disruptor that increases aromatase expression in
some human cancer cell lines. The mechanism involves the inhibition of phosphodiesterase …

Adult stem cells from bone marrow, referred to as mesenchymal stem cells or marrow
stromal cells (MSCs), are defined as pluripotent cells and have the ability to differentiate into …

The adrenal gland plays a pivotal role in an organism's health span by controlling the
endocrine system. Decades of research on the adrenal gland have provided multiscale …

Stem cells are endowed with the potential for self-renewal and multipotency. Pluripotent
embryonic stem cells have an early role in the formation of the three germ layers (ectoderm …

Adrenal insufficiency is managed by hormone replacement therapy, which is far from
optimal; the ability to generate functional steroidogenic cells would offer a unique …

Steroidogenic factor-1 (SF-1, also termed Ad4BP; NR5A1 in the official nomenclature) is a
nuclear receptor transcription factor that plays a crucial role in the regulation of adrenal and …

The adrenal gland controls a plethora of crucial physiological functions, and dysfunction is
associated with severe morbidity. Because of the vital importance of appropriate adrenal …

Brown adipose tissue (BAT) and brownlike cells in white adipose tissue (WAT) can dissipate
energy through thermogenesis, a process mediated by uncoupling protein 1 (UCP1). We …