The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

NMDA receptors (NMDARs) form glutamate‐gated ion channels widely expressed in the
central nervous system and highly permeable to calcium ions. NMDARs have always …

N-Methyl-d-aspartate (NMDA) receptors belong to the family of ionotropic glutamate
receptors, which mediate most excitatory synaptic transmission in mammalian brains …

X-ray crystal structures for the soluble amino-terminal and ligand-binding domains of
glutamate receptor ion channels, combined with a 3.6-Å-resolution structure of the full-length …

AMPA receptors (AMPARs) play a critical role in excitatory glutamatergic neurotransmission.
The number and subunit composition of AMPARs at synapses determines the dynamics of …

The extracellular amino-terminal domains (ATDs) of the ionotropic glutamate receptor
subunits form a semiautonomous component of all glutamate receptors that resides distal to …

Native glutamate receptor ion channels are tetrameric assemblies containing two or more
different subunits. NMDA receptors are obligate heteromers formed by coassembly of two or …

Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate the
majority of excitatory synaptic transmission in the central nervous system. The free energy of …

Ion channels gated by neurotransmitters are present across metazoans, in which they are
essential for brain function, sensation and locomotion; closely related homologs are also …

Excitatory synaptic transmission in the brain is mediated by ligand-gated ion channels
(iGluRs) activated by glutamate. Distinct from other neurotransmitter receptors, the …