The mechanistic/mammalian target of rapamycin (mTOR), a protein discovered in 1991,
integrates a complex pathway with a key role in maintaining cellular homeostasis. By …

Abstract p70 S6 kinase (p70 S6K) is best known for its regulatory roles in protein synthesis
and cell growth by phosphorylating its primary substrate, ribosomal protein S6, upon …

DEPTOR, an inhibitor of mTORC1 and mTORC2, is degraded via ubiquitin-proteasome
pathway by an unknown E3 ubiquitin ligase. Here we report that DEPTOR is a physiological …

DEP domain-containing mechanistic target of rapamycin (mTOR)-interacting protein
(DEPTOR) is an important modulator of mTOR, a kinase at the center of two important …

Aim Deregulation of FOXM1 has been documented in various cancers. The aim of this study
was to evaluate the role of FOXM1 in ovarian cancer tumorigenesis and paclitaxel …

To date, microarray analyses have led to the discovery of numerous individual 'molecular
signatures' associated with specific cancers. However, there are serious limitations for the …

Endometriosis is a well-known risk factor for ovarian cancer. The genetic changes that
characterise endometriosis are poorly understood; however, the mechanistic target of …

Abstract microRNAs (miRNAs/miRs) may have a crucial function in tumor metastasis through
the regulation of a plethora of signaling pathways. Increasing evidence has shown that miR …

Deregulation of the mammalian target of rapamycin (mTOR) signaling pathway has been
found in a variety of human cancers. However, the exact molecular mechanism how the …

Ovarian cancer is fifth in the rankings of cancer deaths among women, and accounts for
more deaths than any other gynecological malignancy. Despite some improvement in …